Molecular profile of BRCA-mutated biliary tract cancers
نویسندگان
چکیده
منابع مشابه
Biliary Tract Cancers: Extrahepatic Management Biliary Tract Cancers
Interventional radiologists fi rst became involved in the management of malignant obstruction of the biliary tree in the late 1960s, when Kaude et al. introduced nonsurgical biliary drainage. Since then, improved diagnostic imaging techniques, significant developments in interventional radiology, and the results of clinical trials have revolutionized and clearly defi ned the role of percutaneou...
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BACKGROUND Biliary tract cancer (BTC) is a rare cancer in Europe and North America, characterized by wide geographic variation, with high incidence in some areas of Latin America and Asia. MATERIALS AND METHODS BTC mortality and incidence have been updated according to recent data, using joinpoint regression analysis. RESULTS Since the 1980s, decreasing trends in BTC mortality rates (age-st...
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Biliary tract cancers (BTCs) are invasive carcinomas that arise from the epithelial lining of the gallbladder and bile ducts. These include intrahepatic, perihilar, and distal biliary tree cancers as well as carcinoma arising from the gallbladder. Complete surgical resection offers the only chance for cure; however, only 10% of patients present with early-stage disease and are considered surgic...
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OPINION STATEMENT A paradigm shift towards molecular-based, personalized cancer therapeutics has occurred in recent years and a number of targeted drugs have emerged. Various targeted therapies like erlotinib, trastuzumab, and cetuximab have been approved in lung, breast, and colon cancers, respectively. Numerous clinical trials involving targeted drugs in biliary tract cancers are currently in...
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Primary biliary diseases have been associated in several studies with various malignancies. Understanding the risk and optimizing surveillance strategy of these malignancies in this specific subset of patients are an important facet of clinical care. For instance, primary sclerosing cholangitis is associated with an increased risk for cholangiocarcinoma (which is very challenging to diagnose) a...
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ژورنال
عنوان ژورنال: ESMO Open
سال: 2020
ISSN: 2059-7029
DOI: 10.1136/esmoopen-2020-000682